Grey Hair and Oxidative Stress Theory

Oxidative Stress Theory: Hydrogen Peroxide & Gray Hair

(Part Two of a Two Part Review)

By: Frederica Hegney

It's no secret that spotting your initial silver strand could be a stressful situation and news reports and articles or blog posts aren't making it much better. From perpetuating myths on fighting gray hair (Drink carrot juice!; Don't pluck the hair strands!) within the raging debate on whether or not to go faux or permit the silver strands go, graying hair is rife with anxiety, confusion and stress.

Well, stop stressing. Knowing the origins of one's graying hair can assist you to debunk irresponsible gray hair myths and take your anxiety down several notches and did we mention that stress only aggravates your graying hair?

Our bodies are always on the look-out for free radicals, also often known as pro-oxidants. When dangerous free radicals enter our bodies (a result of exposure from pollution, very poor dieting, lack of exercise and smoking), specialized enzymes, proteins and vitamins termed antioxidants seek out these damaging radicals and destroy them. Nonetheless, if the body is exposed to an overwhelming volume of free radicals, the antioxidants are unable to destroy all of the pro-oxidants; thus, oxidative stress occurs.

With this second part we will discuss a distinctive class of oxygen based free radicals referred to as Superoxides and see how they wreak havoc by means of the hydrogen peroxide pathway.

Super Oxides are free radicals that results from metabolic activity inside the body such as our response to stress. The body has evolved an elegant strategy of handling these Super Oxides; 1st the body unleashes a category of enzymes called Superoxide Dismutase (SOD) that helps to convert these Superoxides into h2o and hydrogen peroxide. Now in smaller concentrations hydrogen peroxide is easily broken down into hydrogen and h2o by yet another type of enzymes named Peroxidases. The key peroxidases employed by the body are the enzymes Glutathione Peroxidase and Catalase.

Studies have shown that Iodine in combination with selenium increased the activities of type 1 deiodinase (D1) and glutathione peroxidase(GSHPx). Ed. note: Wish I had known THAT when I was in my twenties and my hair was starting to turn grey!

As discussed in Part 1 Gray Hair Free Radicals free radicals in and of themselves can harm the hair follicle and results in graying. Unfortunately, in circumstances of prolonged stress, the amount of hydrogen peroxide being manufactured overwhelms the body's ability to break it down resulting in oxidative stress along with your gray hair. [Arck PC, Overall R, Spatz K et al (2006). Towards a free radical theory of graying: Melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASED J 20: 1567-1569.] The hydrogen peroxide builds up all through the body, including within papillary cavities underneath the epidermis of the scalp. These cavities are the place hair follicles originate, and also where specialized cells - named melanocyte produces melanin for the hair strand.

The hair development cycle has three major stages, which are called the anagen stage (the growth stage), the telogen stage (where the follicle is at a period of rest) and the catagen stage (the transitional period between the former stages). The anagen stage may be decreased into 6 parts; however, melanocyte plays their most significant function in the third and fourth stages. During anagen stage III, melanocyte start to grow and accumulate in the papillary cavities; when the hair follicle starts to grow towards the epidermis, the melanocyte pigments the hair. [TOBIN DJ, SLOMINSKI A, BOTCHKAREV V et all (1999). The Fate of Hair Follicle Melonocytes During the Hair Growth Cycle. J Investig Dermatol Symp Proc 4.323-332].

Now whilst the hair grows in the anagen phase, the accumulated hydrogen peroxide sits in the papillary cavity where it bleaches the hair as it grow no different than if we bleached your hair yourself with a bottle of bleach. Over time it's also most likely the melanocyte cells will die off because the hydrogen peroxide interact with other crucial enzymes such as MSRA and MSRB and deactivate them preventing the hair follicles from repairing itself leading to other aspects of aging hair which includes thinning and weak/brittle hairs leading to wholesale greying.

THIS IS THE END OF A TWO PART SERIES ON OXIDATIVE STRESS THEORY OF GREYING

Frederica Hegney is Moderator of the Grey Defence weblog.
You can also follow her on twitter @GreyHairDefence

Dr. Joe Mercola and Dr. Nicholas Gonzalez discuss pancreatic cancer and its treatment, in the context of Steve Jobs' untimely departure from this world.

Following in the shoes of other Hollywood legends, including Steve McQueen, Michael Landon, and Patrick Swayze, Steve Jobs made one critical decision that may have sealed off his chances for survival. So much could have been done to prevent his illness, and more could have done to facilitate his survival. Sadly, a brilliant billionaire with practically unlimited resources didn't even know what a pancreas was until his own had begun to kill him. In this video, Joe and Nicholas have the guts to tell the truth.

The Demolition of Building 7 on Sept. 11, 2011 = CONTROLLED DEMOLITION, NOT "COLLAPSE DUE TO FIRE"

CONGRESSIONAL REFORM ACT OF 2011

Of the 27 amendments to the Constitution, seven (7) took 1 year or less to become the law of the land... all because of public pressure. If each person contacts a minimum of twenty people then it will only take three days for most people (in the U.S.) to receive the message. It is time to clean up the mess that our legislators have made in Washington.


Please forward this to a minimum of twenty people on your email contacts list; in turn ask each of those to do likewise.

In three days, most people in The United States of America will have the message. This is one idea that really should be passed around.

Congressional Reform Act of 2011

1. No Tenure / No Pension.
A Congressman collects a salary while in office and receives no pay when they are out of office.

2. Congress (past, present & future) participates in Social Security.
All funds in the Congressional retirement fund move to the Social Security system immediately. All future funds flow into the Social Security system, and Congress participates with the American people. It may not be used for any other purpose.

3. Congress can purchase their own retirement plan, just as all Americans do.

4. Congress will no longer vote themselves a pay raise. Congressional pay will rise by the lower of CPI or 3%.

5. Congress loses their current health care system and participates in the same health care system as the American people.

6. Congress must equally abide by all laws they impose on the American people.

7. All contracts with past and present Congressmen are void effective 1/1/12.
The American people did not make this contract with Congressmen. Congressmen made all these contracts for themselves. Serving in Congress is an honor, not a career. The Founding Fathers envisioned citizen legislators, so ours should serve their term(s), then go home and back to work.

If each person contacts a minimum of twenty people then it will only take three days for most people (in the U.S. ) to receive the message. Maybe it is time.

THIS IS HOW YOU FIX CONGRESS!!!!!
If you agree with the above, pass it on.

THOMAS JEFFERSON, AMERICAN STATESMAN AND PATRIOT

Thomas Jefferson was a remarkable man who began his learning very early in life and never stopped.

At 5, he began studying under his cousins' tutor.

At 9, he studied Latin, Greek and French.

At 14, he studied classical literature and additional languages.

At 16, he entered the College of William and Mary.

At 19, he studied Law for 5 years, starting under George Wythe.

At 23, he started his own law practice.

At 25, he was elected to the Virginia House of Burgesses.

At 31, he wrote the widely circulated, "Summary View of the Rights of British America," and retired from his law practice.

At 32, he was a Delegate to the Second Continental Congress, where he wrote the seminal document, “Declaration of the Causes and Necessity of Taking up Arms.”

At 33, he wrote the Declaration of Independence .

At 33, he took three years to revise Virginia 's legal code, wrote a Public Education bill and a statute for Religious Freedom.

At 36, he was elected the second Governor of Virginia, succeeding Patrick Henry.

At 40, he served in Congress for two years.

At 41, he was the American minister to France and negotiated commercial treaties with European nations along with Ben Franklin and John Adams.

At 46, he served as the first Secretary of State under George Washington.

At 53, he served as Vice President and was elected president of the American Philosophical Society.

At 55, he drafted the Kentucky Resolutions and became the active head of the Republican Party.

At 57, he was elected the third president of the United States .

At 60, he obtained the Louisiana Purchase, doubling the nation's size.

At 61, he was elected to a second term as President.

At 65, he retired to Monticello .

At 80, he helped President Monroe shape the Monroe Doctrine.

At 81, he almost single-handedly created the University of Virginia and served as its first president.

At 83, he died, on the 50th anniversary of the Signing of the Declaration of Independence, the same day as his lifelong friend, John Adams…100 miles apart. Adams last words were, “ Jefferson lives.”

Thomas Jefferson knew because he himself had studied the previously failed attempts at government. He understood actual history, the nature of God, God's laws, and the nature of man. That happens to be way more than what most understand today. His is a voice from the past to lead us into the future.
John F. Kennedy held a dinner in the White House for a group of the brightest minds in the nation at that time. He made this statement: "This is perhaps the assembly of the most intelligence ever to gather at one time in the White House with the exception of when Thomas Jefferson dined alone."…a paraphrase of the last sentence of the Eulogy delivered by Governeur Morris (of New York ) at Jefferson’s Funeral: “The greatest collection of Logical Minds in the history of the World was when Jefferson lay dying alone in his Room.”

When we get piled upon one another in large cities, as in Europe, we shall become as corrupt as Europe .
Thomas Jefferson

The democracy will cease to exist when you take away from those who are willing to work and give to those who would not.
Thomas Jefferson

It is incumbent on every generation to pay its own debts as it goes, a principle which if acted on, would save one-half the wars of the world.
Thomas Jefferson

I predict future happiness for Americans if they can prevent the government from wasting the labors of the people under the pretense of taking care of them.
Thomas Jefferson

My reading of history convinces me that most bad government results from too much government.
Thomas Jefferson

No free man shall ever be deprived the use of arms.
Thomas Jefferson

The strongest reason for the people to retain the right to keep and bear arms is, as a last resort, to protect themselves against tyranny in government.
Thomas Jefferson

The tree of liberty must be refreshed from time to time with the blood of patriots and tyrants.
Thomas Jefferson

To compel a man to subsidize with his taxes the propagation of ideas which he disbelieves and abhors is sinful and tyrannical.
Thomas Jefferson

Thomas Jefferson said in 1802:
I believe that banking institutions are more dangerous to our liberties than standing armies. If the American people ever allow private banks to control the issue of their currency, first by inflation, then by deflation, the banks and corporations that will grow up around the banks will deprive the people of all property - until their children wake-up homeless on the continent their fathers conquered.

I wish we could get this out to everyone!!!

I'm doing my part. Please do yours.

Steve Quayle: Part 1 of 12-part series on the signs all around us

OBAMA'S FAKE BIRTH CERTIFICATE

THE GOSPEL

This Video is FLIPPIN' AWESOME !!!

Peek into the Future at Amazing New Technologies on the Way

Frazil ice: a fascinating but hazardous phenomenon

GMO FOOD: HIDDEN DANGERS IN YOUR FOOD

GENETICALLY ENGINEERED FOODS: PART 1 OF 3


GENETICALLY ENGINEERED FOODS: PART 2 OF 3


GENETICALLY ENGINEERED FOODS: PART 3 OF 3

GMO Food: TRILOGY

UNNATURAL SELECTION


JEFFREY SMITH LECTURE


PANACEA OR POISON?

A window into the future...

... and a song that is timeless...

MAKING THE WORLD SAFER FOR MURDERERS, RAPISTS, THIEVES AND TYRANTS

WHY CARRY A GUN?

Why Grandpa carries a gun... PEOPLE ASK WHY? Why Carry a Gun?

My old grandpa said to me 'Son, there comes a time in every man's life
when he stops bustin' knuckles and starts bustin' caps and usually it's
when he becomes too old to take a whoopin'.

I don't carry a gun to kill people. I carry a gun to keep from being
killed.

I don't carry a gun to scare people. I carry a gun because sometimes
this world can be a scary place.

I don't carry a gun because I'm paranoid. I carry a gun because there
are real threats in the world.

I don't carry a gun because I'm evil. I carry a gun because I have
lived long enough to see the evil in the world.

I don't carry a gun because I hate the government. I carry a gun
because I understand the limitations of government.

I don't carry a gun because I'm angry. I carry a gun so that I don't
have to spend the rest of my life hating myself for failing to be
prepared.

I don't carry a gun because I want to shoot someone. I carry a gun
because I want to die at a ripe old age in my bed, and not on a
sidewalk somewhere tomorrow afternoon.


I don't carry a gun because I'm a cowboy. I carry a gun because, when I
die and go to heaven, I want to be a cowboy.


I don't carry a gun to make me feel like a man. I carry a gun because
men know how to take care of themselves and the ones they love.

I don't carry a gun because I feel inadequate. I carry a gun because
unarmed and facing three armed thugs, I am inadequate.


I don't carry a gun because I love it. I carry a gun because I love
life and the people who make it meaningful to me.


Police protection is an oxymoron. Free citizens must protect
themselves. Police do not protect you from crime, they usually just
investigate the crime after it happens and then call someone in to
clean up the mess.


Personally, I carry a gun because I'm too young to die and too old to
take a whoopin'.....author unknown (but obviously brilliant)


********************* A LITTLE GUN HISTORY ********************************
In 1929, the Soviet Union established gun control. From 1929 to 1953,
about 20 million dissidents, unable to defend themselves, were rounded
up and exterminated. ------------------------------
In 1911, Turkey established gun control. From 1915 to 1917, 1.5 million
Armenians, unable to defend themselves, were rounded up and
exterminated. ------------------------------
Germany established gun control in 1938 and from 1939 to 1945, a total
of 13 million Jews and others who were unable to defend themselves were
rounded up and exterminated. ------------------------------
China established gun control in 1935. From 1948 to 1952, 20 million
political dissidents, unable to defend themselves, were rounded up and
exterminated. ------------------------------
Guatemala established gun control in 1964. From 1964 to 1981, 100,000
Mayan Indians, unable to defend themselves, were rounded up and
exterminated. ---- ------------- -------------
Uganda established gun control in 1970. From 1971 to 1979, 300,000
Christians, unable to defend themselves, were rounded up and
exterminated. ------------------------------
Cambodia established gun control in 1956. From 1975 to 1977, one
million educated people, unable to defend themselves, were rounded up
and exterminated. -----------------------------
Defenseless people rounded up and exterminated in the 20th Century
because of gun control: 56 million. ------------------------------
You won't see this data on the US evening news, or hear politicians
disseminating this information.
Guns in the hands of honest citizens save lives and property and, yes,
gun-control laws adversely affect only the law-abiding citizens.
Take note my fellow Americans, before it's too late!
The next time someone talks in favor of gun control, please remind them
of this history lesson.
With guns, we are 'citizens'. Without them, we are 'subjects'.
During WW II the Japanese decided not to invade America because they
knew most Americans were ARMED!
If you value your freedom, please spread this anti gun-control message
to all of your friends.

The purpose of fighting is to win. There is no possible victory in
defense. The sword is more important than the shield, and skill is more
important than either. The final weapon is the brain. All else is
supplemental.

SWITZERLAND ISSUES EVERY HOUSEHOLD A GUN! SWITZERLAND'S GOVERNMENT
TRAINS EVERY ADULT THEY ISSUE A RIFLE. SWITZERLAND HAS THE LOWEST GUN
RELATED CRIME RATE OF ANY CIVILIZED COUNTRY IN THE WORLD!!!
IT'S A NO BRAINER! DON'T LET OUR GOVERNMENT WASTE MILLIONS OF OUR TAX
DOLLARS IN AN EFFORT TO MAKE ALL LAW ABIDING CITIZENS AN EASY TARGET.

I'm a firm believer in the 2nd Amendment! If you are too, please
pass this on.

INNOCENTS BETRAYED: THE HISTORY OF GUN CONTROL

THIS IS PART 1 OF A 6-PART SERIES ON YOUTUBE. TO SEE THE OTHER 5, CLICK ON THE YOUTUBE LOGO.

Steven Young takes the mayor to task on the 2nd Amendment

FRACKING HELL; THE UNTOLD STORY

MINI ICE AGE IS BEGINNING: PIERS CORBIN EXPLAINS ITS CAUSES

Alex Jones also talks with meteorologist and astrophysicist Piers Corbyn. He is the owner of Weather Action which makes weather forecasts up to a year in advance. Corbyn is well-known for his opposition to the idea of anthropogenic global warming. Alex also covers the latest news and takes your calls.

The dominant driving forces of our weather are the sun and moon. These in turn are controlled by electrical currents flowing through space called "Birkeland Currents". It is as if the universe has nerve fibers along which messages travel, controlling the "cells", which are stars and planets. What is happening to our climate is analogous to a body (our planet as a cell in the Universe) being affected by a thought in the mind of God.

In this video, Piers Corbin explains the interactions between the solar wind, the moon, and our weather, and explains why his predictions are so accurate. We're in for a rough ride, folks. If you haven't done it already, it's time to come to Jesus.

In the following video, Piers is interviewed on Russia Today, and explains the heat wave, drought, and wildfires experienced in Russia and the Ukraine last season... and why they will continue. Russia cancelled ALL wheat exports last year, and will be short of food if this continues.